It seems to me that, at least in some cases, the problem is we don't like the answer.
For example: what is the meaning of life? Well science tells us that we are the product of millions of years of evolution and that, on the grand scale, there is no meaning beyond the propagation of genes. I don't see why that answer should be considered inadequate.
That's a good example of a question that seems coherent but when looked at closely seems to break down to something that is empty. I don't think it makes sense to look at it as a question for science since there is an implied 'ought' in it, and science only does what is.
The reason that it seems to break down to me are the 'answers' thar people have gone for which seem not to be about meaning but a yearning for direction. To take the dominant strand in Christianity, it seems to be a scorecard rather than what I would think of as meaning.
As is often answered, on here people find a 'meaning' in what they find rewarding, family, music, meditation, biscuits... And that seems to be about accepting the limits of what can be known and using 'meaning' as another form of scorecard.
