When I started reading the report below, I was thinking in my head 'Isn't this old news?' and then I got to the quote "The fundamental importance of oxygen has been understood for centuries, but how cells adapt to changes in levels of oxygen has long been unknown." It's interesting that it's so easy to forget that awareness of something isn't understanding. And that while we may be in many areas in science filling in the fractal gaps in knowledge, those gaps are fundamental and hugely rewarding.
John Horgan wrote a book as the turn of the millennium approached called ' The End of Scince' and argued that we were going to just be filling in the gaps. At the time I though it both flawed in the argument, but this reveals that the gaps themselves are perhaps more interesting. To be fair, it was part of a sort of millennial fever that every subject had a book about The End Of... The more sensible ones included a question mark in the title.
https://www.bbc.co.uk/news/health-49959737