I have written about the Cholesterol Controversy and the myth of cholesterol link to heart disease many years back.
Here is a recent article on this.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513492/************
The cholesterol hypothesis links cholesterol intake and blood levels to cardiovascular disease. Because cholesterol is considered a risk factor for atherosclerosis many believe that lowering cholesterol in the blood is the best way to prevent CHD.
Reducing cholesterol blood levels by reducing dietary saturated fats is commonly recommended, but an exhaustive review and meta-analysis of 72 dietary studies concluded that reduced consumption of saturated fat does not reduce cardiovascular mortality.
Thus, the hypothesis that lowering cholesterol lowers mortality from CHD is not supported by many clinical research studies.
Early statin trials reported significant mortality benefits, yet serious concerns have been raised in some studies regarding biased results, premature trial terminations, under reporting of adverse events, high numbers of patients lost to follow-up and oversight by the pharmaceutical company sponsor.
Curiously, statin trials conducted after 2005 have failed to demonstrate a consistent mortality benefit[10].
Coronary heart disease is an extremely complex malady and the expectation that it could be prevented or eliminated by simply reducing cholesterol appears unfounded. After twenty years we should concede the anomalies of the cholesterol hypothesis and refocus our efforts on the proven benefits of a healthy lifestyle incorporating a Mediterranean diet to prevent CHD[2-4,41,42].
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