That Natural Selection is a metaphor is a fact.
Also, evolution may not be entirely gene centric.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3060581/#:~:text=Neo%2DDarwinism%20is%20the%20term,correct%20since%20Romanes%20coined%20the**********
This article argues that the gene-centric interpretations of evolution, and more particularly the selfish gene expression of those interpretations, form barriers to the integration of physiological science with evolutionary theory.
understanding biological function through physiological analysis requires an integrative approach in which the activity of the proteins and RNAs formed from each DNA template is analysed in networks of interactions. These networks also include components that are not specified by nuclear DNA. Inheritance is not through DNA sequences alone.
The DNA molecule on its own does absolutely nothing since it reacts biochemically only to triggering signals. It cannot even initiate its own transcription or replication. It cannot therefore be characterised as selfish in any plausible sense of the word. If we extract DNA and put it in a Petri dish with nutrients, it will do nothing. The cell from which we extracted it would, however, continue to function until it needs to make more proteins, just as red cells function for a hundred days or more without a nucleus. It would therefore be more correct to say that genes are not active causes; they are, rather, caused to give their information by and to the system that activates them. The only kind of causation that can be attributed to them is passive, much in the way a computer program reads and uses databases.
While the vehicle is also ‘inherited’ (genes on their own do nothing and certainly are not sufficient to ‘make’ an organism – since we must also inherit a complete fertilised egg cell), the story goes that changes in the vehicle are not inherited (so no inheritance of acquired characteristics) while changes in the replicator (e.g. mutations) are inherited. This approach is what enables the wholesale inheritance of the vehicle to be ignored.
Yet, the vehicle (the cell, or each cell in a multicellular organism) clearly does reproduce (indeed, it is only through this reproduction that DNA itself is transmitted), and in doing so it passes on all the phenotype characteristics for which there are no nuclear DNA templates and which are necessary to interpret the inherited DNA.
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